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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8621
Title: Uric Acid Levels Are Associated with Bone Mineral Density in Mexican Populations: A Longitudinal Study
Keywords: Mexican population; bone mineral density; uric acid levels.
Issue Date: 2022
Publisher: PMC
Abstract: Abstract Background: Inconsistent epidemiological evidence between uric acid (UA) and bone mineral density (BMD) has been observed. Therefore, we evaluated the association between UA and BMD in Mexican adults. Methods: This analysis was conducted on 1423 participants from the Health Workers Cohort Study. We explored cross-sectional associations using linear regression and longitudinal associations using fixed-effects linear regression by sex and age groups (45 and 45 years). Results: In females 45 years old, the cross-sectional analysis showed that UA levels were positively associated with total hip BMD. However, in the longitudinal analysis, we observed a negative association with the femoral neck and lumbar spine BMD. In contrast, in males 45 years old, we found an increase in total hip and femoral neck BMD in the groups with high levels of UA in the longitudinal association. On the other hand, in females 45 years old, we observed a longitudinal association between UA and loss of BMD at different sites. We did not observe an association between UA levels and BMD in males 45 years old. Conclusions: Our results suggest higher serum UA levels are associated with low BMD at different skeletal sites in Mexican females. Further studies are needed to delineate the underlying mechanisms behind this observation.
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612067/pdf/nutrients-14-04245.pdf
https://doi.org/10.3390/nu14204245
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8621
ISSN: 2072-6643
Appears in Collections:Artículos

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