DSpace JSPUI


DSpace preserves and enables easy and open access to all types of digital content including text, images, moving images, mpegs and data sets

Learn More

Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8468
Full metadata record
DC FieldValueLanguage
dc.coverage.spatialnacional-
dc.creatorORTIGOZA, ANA-
dc.date.accessioned2024-04-29T22:42:07Z-
dc.date.available2024-04-29T22:42:07Z-
dc.date.issued2021-
dc.identifier.issn1873-6750-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0160412021002373?via%3Dihub-
dc.identifier.urihttps://doi.org/10.1016/j.envint.2021.106612-
dc.identifier.urihttp://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8468-
dc.description.abstractAbstract Background: Pregnancy induces numerous cardiovascular and metabolic changes. Alterations in these sensitive processes may precipitate long-term post-delivery health consequences. Studies have reported associations between phthalates and metabolic complications of pregnancy, but no study has investigated metabolic outcomes beyond pregnancy. Objectives: To examine associations of exposure to phthalates during pregnancy with post-delivery metabolic health. Design: We quantified 15 urinary phthalate biomarker concentrations during the second and third trimesters among 618 pregnant women from Mexico City. Maternal metabolic health biomarkers included fasting blood measures of glycemia [glucose, insulin, Homeostatic Model Assessment of Insulin Resistance [HOMA-IR], hemoglobin A1c (HbA1c)] and lipids (total, high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol, triglycerides), at 4-5 and 6-8 years post-delivery. To estimate the influence of the phthalates mixture, we used Bayesian weighted quantile sum regression and Bayesian kernel machine regression; for individual biomarkers, we used linear mixed models. Results: As a mixture, higher urinary phthalate biomarker concentrations during pregnancy were associated with post-delivery concentrations of plasma glucose (interquartile range [IQR] difference: 0.13 SD, 95CrI: 0.05, 0.20), plasma insulin (IQR difference: 0.06 SD, 95CrI: -0.02, 0.14), HOMA-IR (IQR difference: 0.08 SD, 95 CrI: 0.01, 0.16), and HbA1c (IQR difference: 0.15 SD, 95CrI: 0.05, 0.24). Associations were primarily driven by mono-2-ethyl-5-carboxypentyl terephthalate (MECPTP) and the sum of dibutyl phthalate biomarkers (DBP). The phthalates mixture was associated with lower HDL (IQR difference: -0.08 SD, 95CrI: -0.16, -0.01), driven by DBP and monoethyl phthalate (MEP), and higher triglyceride levels (IQR difference: 0.15 SD, 95CrI: 0.08, 0.22), driven by MECPTP and MEP. The overall mixture was not associated with total cholesterol and LDL. However, DBP and MEP were associated with lower and higher total cholesterol, respectively, and MECPTP and DBP were associated with lower LDL. Conclusions: Phthalate exposure during pregnancy is associated with adverse long-term changes in maternal metabolic health. A better understanding of timing of the exact biological changes and their implications on metabolic disease risk is needed.-
dc.formatpdf-
dc.languageeng-
dc.publisherElsevier Science-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.subjectBayes Theorem Biomarkers Blood Glucose Environmental Exposure / adverse effects Environmental Exposure / analysis Environmental Pollutants* / toxicity Female Humans Lipids Phthalic Acids* / toxicity Pregnancy nan-
dc.titleThe associations of phthalate biomarkers during pregnancy with later glycemia and lipid profiles-
dc.typeinfo:eu-repo/semantics/article-
dc.subject.ctiinfo:eu-repo/classification/cti/3-
dc.creator.orcidorcid/0000-0001-8100-422X;ORTIGOZA, ANA-
dc.creator.orcidorcid/0000-0002-3436-0640;Baccarelli, Andrea-
dc.creator.orcidorcid/0000-0002-5239-3235;Braun, Joseph-
dc.creator.orcidorcid/0000-0002-1397-8476;CANTORAL, ALEJANDRA-
dc.creator.orcidorcid/0000-0002-1875-8448;Colicino, Elena-
dc.creator.orcidorcid/0000-0001-9658-7050;Diez Roux, Ana-
dc.creator.orcidorcid/0000-0003-4312-5957;Just, Allan-
dc.creator.orcidorcid/0000-0003-2513-3339;Oken, Emily-
dc.creator.orcidorcid/0000-0002-3178-1482;Pantic, Ivan-
dc.creator.orcidorcid/0000-0002-2190-6421;PIZANO-ZARATE, MARIA LUISA-
dc.creator.orcidorcid/0000-0003-3322-3334;Téllez Rojo, Martha-
dc.creator.orcidorcid/0000-0003-1180-6459;Wright, Robert-
Appears in Collections:Artículos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.