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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8418
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DC FieldValueLanguage
dc.coverage.spatialnacional-
dc.creatorEchaniz Avilés, Irma Gabriela-
dc.date.accessioned2024-04-29T22:42:01Z-
dc.date.available2024-04-29T22:42:01Z-
dc.date.issued2021-
dc.identifier.issn1873-2518-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0264410X21011117?via%3Dihub-
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2021.08.063-
dc.identifier.urihttp://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8418-
dc.description.abstractBackground: Low vaccination rates and under-detection of pertussis infections in adolescents and young adults have an impact on the transmission of pertussis to infants. In this study, the proportion of adolescents and young adults with IgG antibodies against B. pertussis antigens, representing recent infection or vaccination, was estimated in a population-based probabilistic survey in Mexico. Methods: Sera and data from 1,581 subjects, including 1,102 adolescents and 479 young adults (10-19 and 20-25 years old, respectively) randomly selected from Mexicos 2012 National Health and Nutrition Survey, were analyzed. IgG antibodies against pertussis toxin (PT) were measured with the CDCFDA ELISA. A subset of 234 samples was additionally tested with Bp-IgG PT ELISA kit (EUROIMMUN AG, Lubeck, Germany). Threshold values from corresponding test kits were used to identify recent infection or vaccination. Results: Overall anti-PT IgG seroprevalence was 3.9 (95 CI: 2.3-6.3); 3.1 (95 CI: 1.9-5.0) in adolescents, and 4.9 (95 CI: 2.2-11) in young adults. Seroprevalence did not significantly vary by sex, socioeconomic status, region or ruralurban location. Compared to the CDCFDA ELISA, the EUROIMMUN test showed a 76 sensitivity and 88 specificity. The weighted estimates represent a considerable burden of recent infection in adolescents and young adults; however, most adolescents and adults were seronegative and, therefore, susceptible to pertussis infection. Conclusion: Since booster vaccination to B. pertussis after toddlerhood is not recommended in the Mexican national policy, anti-PT IgG seropositivity may be reasonably attributed to recent infection. Assessing pertussis seroprevalence requires careful consideration of the diagnostic test threshold interpretation and epidemiological model used.-
dc.formatpdf-
dc.languageeng-
dc.publisherElsevier Science-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.subjectAdolescent; Bordetella pertussis; Humans; Infant; Mexico / epidemiology; Nutrition Surveys; Seroepidemiologic Studies; Whooping Cough* / diagnosis; Whooping Cough* / epidemiology; Young Adult; Adolescents; ENSANUT; Mexico; Pertussis; Seroprevalence.-
dc.titleEstimating Bordetella pertussis seroprevalence in adolescents and young adults in Mexico using the 2012 National Health and Nutrition Survey (ENSANUT)-
dc.typeinfo:eu-repo/semantics/article-
dc.subject.ctiinfo:eu-repo/classification/cti/3-
dc.creator.curpcurp/EAAI610308MDFCVR07;Echaniz Avilés, Irma Gabriela-
dc.creator.orcidorcid/0000-0002-3167-0168;Echaniz Avilés, Irma Gabriela-
dc.creator.orcidorcid/0000-0002-5405-5256;Alpuche_Aranda, Celia-
dc.creator.orcidorcid/0000-0001-5600-6979;Cortes-Alcala, Ricardo-
dc.creator.orcidorcid/0000-0003-2586-4115;DeAntonio, Rodrigo-
dc.creator.orcidorcid/0000-0002-3167-0168;Echaniz Avilés, Irma Gabriela-
dc.creator.orcidorcid/0000-0002-2302-9100;García-Cisneros, Santa-
dc.creator.orcidorcid/0000-0002-5227-7541;Olamendi-Portugal, Maria-
dc.creator.orcidorcid/0000-0003-4980-7713;Ortega-Barria, Eduardo-
dc.creator.orcidorcid/0000-0003-3363-757X;Romero, Martin-
dc.creator.orcidorcid/0000-0003-2383-7930;Sánchez-Aleman, Miguel Angel-
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