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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8401
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dc.coverage.spatialnacional-
dc.creatorMiller, Cheryl N-
dc.date.accessioned2024-04-29T22:41:59Z-
dc.date.available2024-04-29T22:41:59Z-
dc.date.issued2021-
dc.identifier.issn1873-2518-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0264410X21009622?via%3Dihub-
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2021.07.069-
dc.identifier.urihttp://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8401-
dc.description.abstractStrong quantitative and functional antibody responses to the quadrivalent human papillomavirus (HPV) vaccine were reported in mid-adult aged men, but there are limited data on the avidity of the antibody response and the memory B-cell response following vaccination. Although circulating antibodies induced by vaccination are believed to be the main mediators of protection against infection, evaluation of avidity of antibodies and memory B cell responses are critical for a better understanding of the vaccine immunogenicity mechanisms. Both the modified enzyme-linked immunosorbent assay (ELISA) and the enzyme-linked immunosorbent spot (ELISpot) assay are tools to measure the humoral and cellular immune responses post vaccination to characterize vaccine immunogenicity. The avidity of HPV-16 and HPV-18 specific IgG in the serum of mid-adult aged men (N 126) who received three quadrivalent HPV vaccine doses was examined using a modified ELISA. HPV-16 memory B-cell responses were assessed via ELISpot at month 0 (prior to vaccination) and 1-month post-dose three of the vaccine (month 7). The quadrivalent vaccine induced an increase in HPV-16 and HPV-18 antibody avidity at month 7. HPV-18 avidity levels moderately correlated with anti-HPV-18 antibody titers, but no association was observed for HPV-16 antibody titers and avidity levels. The HPV-16-specific memory B-cell response was induced following three vaccine doses, however, no association with anti-HPV-16 antibody avidity was observed. Three doses of quadrivalent HPV vaccine increased antibody affinity maturation for HPV-1618 and increased the frequency of anti-HPV-16 memory B-cells in mid-adult aged men.-
dc.formatpdf-
dc.languageeng-
dc.publisherElsevier Science-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.subjectAdult; Aged; Antibodies, Viral; Antibody Affinity; B-Lymphocytes; Human papillomavirus 16; Human papillomavirus 18; Humans; Male; Papillomavirus Infections / prevention & control; Papillomavirus Vaccines; nan-
dc.titleIncreases in HPV-1618 antibody avidity and HPV-specific memory B-cell response in mid-adult aged men post-dose three of the quadrivalent HPV vaccine-
dc.typeinfo:eu-repo/semantics/article-
dc.subject.ctiinfo:eu-repo/classification/cti/3-
dc.creator.orcidorcid/0000-0003-3665-704X;Miller, Cheryl N-
dc.creator.orcidorcid/0000-0001-7252-9446;Abrahamsen, Martha-
dc.creator.orcidorcid/0000-0002-5440-8859;Giuliano, Anna R-
dc.creator.orcidorcid/0000-0002-1197-7525;Kemp, Troy-
dc.creator.orcidorcid/0000-0003-1259-6369;LAZCANO PONCE, EDUARDO CESAR-
dc.creator.orcidorcid/0000-0003-3665-704X;Miller, Cheryl N-
dc.creator.orcidorcid/0000-0003-2218-7411;Pan, Yuanji-
dc.creator.orcidorcid/0000-0001-8654-2393;SALMERON CASTRO, JORGE-
dc.creator.orcidorcid/0000-0002-5089-3666;Sirak, Bradley-
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