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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8374
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dc.coverage.spatialnacional-
dc.creatorAlvarado Delgado, Alejandro-
dc.date.accessioned2024-04-29T22:41:55Z-
dc.date.available2024-04-29T22:41:55Z-
dc.date.issued2021-
dc.identifier.issn1528-3658-
dc.identifier.urifile:///C:/Users/atalani/Downloads/s10020-021-00311-5.pdf-
dc.identifier.urihttps://doi.org/10.1186/s10020-021-00311-5.-
dc.identifier.urihttp://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8374-
dc.description.abstractAbstract Objective: To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism. Methods: Hypervariable V3-V4 regions of the bacterial 16S rRNA gene from fecal samples of gout patients with and without tophi (n 33 and n 25, respectively) were sequenced and compared to fecal samples from 53 healthy controls. We explored predictive functional profiles using bioinformatics in order to identify differences in taxonomy and metabolic pathways. Results: We identified a microbiome characterized by the lowest richness and a higher abundance of Phascolarctobacterium, Bacteroides, Akkermansia, and Ruminococcusgnavusgroup genera in patients with gout without tophi when compared to controls. The Proteobacteria phylum and the Escherichia-Shigella genus were more abundant in patients with tophaceous gout than in controls. Fold change analysis detected nine genera enriched in healthy controls compared to gout groups (Bifidobacterium, Butyricicoccus, Oscillobacter, RuminococcaceaeUCG010, LachnospiraceaeND2007group, Haemophilus, Ruminococcus1, Clostridiumsensustricto1, and RuminococcaceaeUGC013). We found that the core microbiota of both gout groups shared Bacteroides caccae, Bacteroides stercoris ATCC 43183, and Bacteroides coprocola DSM 17136. These bacteria might perform functions linked to one-carbon metabolism, nucleotide binding, amino acid biosynthesis, and purine biosynthesis. Finally, we observed differences in key bacterial enzymes involved in urate synthesis, degradation, and elimination. Conclusion: Our findings revealed that taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism.-
dc.formatpdf-
dc.languageeng-
dc.publisherBioMed Central-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.subjectBiodiversity Computational Biology / methods Dysbiosis* Gastrointestinal Microbiome* Gout / etiology Gout / metabolism* Gout / pathology Humans Metagenome* Metagenomics* / methods Protein Interaction Mapping Protein Interaction Maps Uric Acid / metabolism* nan-
dc.titleTaxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism-
dc.typeinfo:eu-repo/semantics/article-
dc.subject.ctiinfo:eu-repo/classification/cti/3-
dc.creator.orcidorcid/0000-0003-2348-379X;Alvarado Delgado, Alejandro-
dc.creator.orcidorcid/0000-0003-4645-2494;Burguete-Garcia, Ana I.-
dc.creator.orcidorcid/0000-0003-4646-0849;ÇUBUK, Cankut-
dc.creator.orcidorcid/0000-0002-7271-2862;Fernández-Torres, Javier-
dc.creator.orcidorcid/0000-0002-1206-0161;Lagunas-Martínez, Alfredo-
dc.creator.orcidorcid/0000-0003-3083-4797;Lanz_Mendoza, Humberto-
dc.creator.orcidorcid/0000-0001-8809-6526;Lozada Pérez, Carlos Alberto-
dc.creator.orcidorcid/0000-0001-9857-3840;MARTINEZ NAVA, GABRIELA ANGELICA-
dc.creator.orcidorcid/0000-0003-0675-0227;Martínez-Flores, Karina-
dc.creator.orcidorcid/0000-0001-7397-9019;Orbe-Orihuela, Yaneth Citlalli-
dc.creator.orcidorcid/0000-0002-7848-1532;Palacios-Gonzalez, Berenice-
dc.creator.orcidorcid/0000-0003-1774-2580;Sánchez Casimiro-Soriguer, Carlos-
dc.creator.orcidorcid/0000-0001-5764-9343;Silveira, Luis H.-
dc.creator.orcidorcid/0000-0002-1103-3006;Vazquez-Gomez, Alonso-
dc.creator.orcidorcid/0000-0001-6636-2301;Vazquez_Mellado, Janitzia-
dc.creator.orcidorcid/0000-0003-1751-3454;Zamudio-Cuevas, Yessica-
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