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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8231
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dc.coverage.spatialnacional
dc.creatorMorales-Sánchez, Abigail
dc.date.accessioned2023-05-25T14:21:31Z-
dc.date.available2023-05-25T14:21:31Z-
dc.date.issued2020
dc.identifier.urisicabi.insp.mx:2020-None
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459453/pdf/pathogens-09-00623.pdf
dc.identifier.urihttps://www.doi.org/ 10.3390/pathogens9080623
dc.identifier.urihttp://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8231-
dc.description.abstractAbstract In this study, we assessed the presence of Epstein-Barr virus (EBV) in gastric samples derived from pediatric patients with dyspeptic symptoms, aiming to understand whether EBV participates in the development of early gastric lesions influencing chronic inflammation, in conjunction with the Helicobacter pylori (Hp) bacterium. We analyzed EBV load in 236 gastric biopsies derived from 186 pediatric patients with chronic dyspepsia and compared it with EBV serology, Hp load and serology, and with immune cell infiltration. We found that 7.5% of patients were positive for EBV load, ranging from 240 to 29,685 genomic copies/μg of DNA. Hp genomic sequences were found in 24.7% of patients. EBV positive samples did not correlate with Hp status and were characterized by absent to moderate immune cell infiltration. To our knowledge, this is the first study addressing EBV load in the stomach in a large cohort of pediatric patients with dyspeptic symptoms, providing evidence of EBV localization in the gastric mucosa in early inflammatory lesions. The lack of correlation between EBV and both Hp infection and inflammation is perhaps explained by independent pathogenic mechanisms or because of the randomness of the gastritis sampling. This is also supported by a moderate association between EBV load and serology.
dc.formatpdf
dc.languagespa
dc.publisherESPM INSP
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectHost-Pathogen Interactions, Microbiological Phenomena
dc.titleDetection of Epstein-Barr Virus DNA in Gastric Biopsies of Pediatric Patients with Dyspepsia
dc.typeinfo:eu-repo/semantics/article
dc.subject.ctiinfo:eu-repo/classification/cti/3
dc.creator.orcidorcid/0000-0003-2951-6716;Morales-Sánchez, Abigail
dc.creator.orcidorcid/0000-0002-8339-664X;Flores Luna, Genoveva Lourdes
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