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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8223
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DC FieldValueLanguage
dc.coverage.spatialnacional
dc.creatorLee, Crystal
dc.date.accessioned2023-05-25T14:21:29Z-
dc.date.available2023-05-25T14:21:29Z-
dc.date.issued2020
dc.identifier.urisicabi.insp.mx:2020-None
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936411/pdf/bmjdrc-2019-000794.pdf
dc.identifier.urihttps://www.doi.org/ 10.1136/bmjdrc-2019-000794
dc.identifier.urihttp://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8223-
dc.description.abstractAbstract Objective: There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods: We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results: Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions: In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.
dc.formatpdf
dc.languagespa
dc.publisherESPM INSP
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectBiomarkers , analysis Diabetes Mellitus, Type 1 , epidemiology Diabetes Mellitus, Type 1 , pathology, Diabetes Mellitus, Type 2 , epidemiology Diabetes Mellitus, Type 2 , pathology, Disease Progression Humans Incidence Prediabetic State , physiopathology, Prognosis Risk Factors
dc.titleComparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes
dc.typeinfo:eu-repo/semantics/article
dc.subject.ctiinfo:eu-repo/classification/cti/3
dc.creator.orcidorcid/0000-0001-6613-5491;Lee, Crystal
dc.creator.orcidorcid/0000-0002-6470-2517;Azizi, Fereidoun
dc.creator.orcidorcid/0000-0002-2398-4781;Colagiuri, Stephen
dc.creator.orcidorcid/0000-0003-2419-1086;Gonzalez Villalpando, Cliserio
dc.creator.orcidorcid/0000-0003-2381-6822;Gregg, Edward
dc.creator.orcidorcid/0000-0001-9800-5296;Woodward, Mark
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