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http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8149| Title: | Determination of insecticides’ lethal concentrations and metabolic enzyme levels in Triatoma dimidiata |
| Keywords: | Acetylcholinesterase , analysis Animals Cytochrome P-450 Enzyme System , analysis Esterases , analysis Feasibility Studies Glutathione Transferase , analysis Insecticide Resistance, Insecticides , toxicity, Lethal Dose 50 Malathion , toxicity, Mixed Function Oxygenases , analysis Nitriles , toxicity, Nymph , drug effects Nymph , enzymology Propoxur , toxicity, Pyrethrins , toxicity, Triatoma , drug effects, Triatoma , enzymology World Health Organization |
| Issue Date: | 2020 |
| Publisher: | ESPM INSP |
| Abstract: | Abstract in English, Spanish Objective: The feasibility of the use of WHO impregnated paper and biochemical assays to determine lethal concentrations (LC50 and LC99) and insecticide metabolic enzyme levels of Triatoma dimidiata. Materials and methods: LC50 and LC99 were calculated with WHO papers impregnated at different concentrations of malathion, propoxur and deltamethrin; the percentage of insensitive acetylcholinesterase (iAChE); and the levels of esterases, glutathione S-transferases, and monooxygenases in laboratory nymphs of the first stage (5 to 7 days), were undertaken using the WHO biochemical assays. Results: Respectively the LC50 and LC99 μg/cm2 obtained for malathion were 43.83 and 114.38, propoxur 4.71 and 19.29, and deltamethrin 5.80 and 40.46. A 30% of the population had an iAChE, and only a few individuals had high P450 and β-eterase levels. Conclusions: Impregnated papers and biochemical tests developed by WHO for other insects, proved to be feasible methods in monitoring insecticide resistance and metabolic enzymes involved in T. dimidiata. |
| URI: | sicabi.insp.mx:2020-None https://saludpublica.mx/index.php/spm/article/view/10133/11884 https://www.doi.org/ 10.21149/10133 http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8149 |
| Appears in Collections: | Artículos |
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