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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/7932
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DC FieldValueLanguage
dc.coverage.spatialnacional
dc.creatorFernandez Salas, Ildefonso
dc.date.accessioned2022-02-16T04:22:52Z-
dc.date.available2022-02-16T04:22:52Z-
dc.date.issued2017
dc.identifier.urisicabi.insp.mx:2017-None
dc.identifier.urihttps://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5355569
dc.identifier.urihttps://www.doi.org/10.1016/j.stemcr.2017.01.008.
dc.identifier.urihttp://repositorio.insp.mx:8080/jspui/handle/20.500.12096/7932-
dc.description.abstractZika virus (ZIKV) infection causes microcephaly in a subset of infants born to infected pregnant mothers. It is unknown whether human individual differences contribute to differential susceptibility of ZIKV-related neuropathology. Here, we use an Asian-lineage ZIKV strain, isolated from the 2015 Mexican outbreak (Mex1-7), to infect primary human neural stem cells (hNSCs) originally derived from three individual fetal brains. All three strains of hNSCs exhibited similar rates of Mex1-7 infection and reduced proliferation. However, Mex1-7 decreased neuronal differentiation in only two of the three stem cell strains. Correspondingly, ZIKA-mediated transcriptome alterations were similar in these two strains but significantly different from that of the third strain with no ZIKV-induced neuronal reduction. This study thus confirms that an Asian-lineage ZIKV strain infects primary hNSCs and demonstrates a cell-strain-dependent response of hNSCs to ZIKV infection.
dc.formatpdf
dc.languagespa
dc.publisherESPM INSP
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectStem Cells,Zika virus, astrocyte differentiation human neural stem cell innate immunity neurogenesis neuron proliferation transcriptome
dc.titleDifferential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection
dc.typeinfo:eu-repo/semantics/article
dc.subject.ctiinfo:eu-repo/classification/cti/3
dc.creator.orcidorcid/0000-0002-8605-9630;Fernandez Salas, Ildefonso
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