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Please use this identifier to cite or link to this item: http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/7921
Title: 3D-Hydrogel Based Polymeric Nanoreactors for Silver Nano-Antimicrobial Composites Generation
Keywords: Nanostructures,Nanotechnology,Ag nanoparticles, antibacterial materials polyurethane networks silver-hydrogel nanocomposites smart-hydrogel thiol-acrylate networks.
Issue Date: 2017
Publisher: ESPM INSP
Abstract: This study underscores the development of Ag hydrogel nanocomposites, as smart substrates for antibacterial uses, via innovative in situ reactive and reduction pathways. To this end, two different synthetic strategies were used. Firstly thiol-acrylate (PSA) based hydrogels were attained via thiol-ene and radical polymerization of polyethylene glycol (PEG) and polycaprolactone (PCL). As a second approach, polyurethane (PU) based hydrogels were achieved by condensation polymerization from diisocyanates and PCL and PEG diols. In fact, these syntheses rendered active three-dimensional (3D) hydrogel matrices which were used as nanoreactors for in situ reduction of AgNO₃ to silver nanoparticles. A redox chemistry of stannous catalyst in PU hydrogel yielded spherical AgNPs formation, even at 4 °C in the absence of external reductant; and an appropriate thiol-functionalized polymeric network promoted spherical AgNPs well dispersed through PSA hydrogel network, after heating up the swollen hydrogel at 103 °C in the presence of citrate-reductant. Optical and swelling behaviors of both series of hydrogel nanocomposites were investigated as key factors involved in their antimicrobial efficacy over time. Lastly, in vitro antibacterial activity of Ag loaded hydrogels exposed to Pseudomona aeruginosa and Escherichia coli strains indicated a noticeable sustained inhibitory effect, especially for Ag-PU hydrogel nanocomposites with bacterial inhibition growth capabilities up to 120 h cultivation.
URI: sicabi.insp.mx:2017-None
https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5575691
https://www.doi.org/10.3390/nano7080209
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/7921
Appears in Collections:Artículos

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